![]() ![]() Too many project management methods have failed not because they weren't adding value but because you couldn't measure the effectiveness of the methodology or quantify the value added by process changes. Generally, professional project management attempts to achieve these goals by encouraging best practices on a project-by-project basis, often through the mechanism of a project office that promulgates policy, provides templates and advice, promotes appropriate use of tools such as critical path method, and perhaps performs periodic project reviews. Both disciplines seek to reduce failures, prevent defects, control costs and schedules, and manage risk. Six Sigma is complementary with existing project management programmes and standards but differs in significant ways. It is more than that because it is a robust continuous improvement strategy and process that includes cultural and statistical methodologies. Therefore, based on preclinical studies, this review discusses whether the sigma-1 receptor could be a promising target for drugs treating affective and cognitive disorders.Six Sigma is not just a new term for project management nor is it a mere repackaging of old concepts. Importantly, two sigma-1 receptor ligands entered clinical trials, showing that this compound group possesses therapeutic potential. Thus, sigma-1 receptor modulation might be useful in treating these central nervous system diseases. Changes in their functions and expression may lead to various diseases, including depression or memory impairments. Sigma-1 receptors are multi-functional proteins localized in endoplasmic reticulum membranes, which play a crucial role in cellular signal transduction by interacting with receptors, ion channels, lipids, and kinases. Proteins attracting much attention as potential targets for drugs treating these conditions are sigma-1 receptors. Since the current treatments are inadequate in many patients, there is a constant need for discovering new compounds, which will be more effective in ameliorating depressive symptoms and treating cognitive decline. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of both conditions. Depression and cognitive disorders are diseases with complex and not-fully understood etiology. ![]()
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December 2022
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